Topic	Director	Allocated funds
1	Assessment of the state of metabolism and bone mineral density in adolescent girls with primary dysmenorrhea in the Kazakh population	Amanzholovna A.	12506688
2	Recurrent tuberculosis of the respiratory system: monitoring and causes contributing to the development of tuberculosis	Dilmagambetov D. S.	6122063, 20
3	The use of platelet-enriched autoplasma for the prevention of urological complications in kidney recipients	Musin N. M.	8673385
4	A personalized approach to dietary therapy for patients with type 2 diabetes in primary health care	Sartaeva A. S.	4013769,20
5	Psychosomatic diseases: determining the actual prevalence and associated factors, adapting international diagnostic methods and developing a burden reduction program in Kazakhstan: a pilot project in Aktobe	Zhamalieva L. M.	8147028
6	The effect of vitamin D on the neuroendocrine regulation of the menstrual cycle in adolescent girls with primary dysmenorrhea	Kaldybaeva A. T.	9374121,80
7	Concomitant bacterial infections and pharmacoepidemiology of antibiotic resistance in patients with COVID-19: the situation in Aktobe region	Smagulova G. A.	7844289,16
8	Prevention of preeclampsia by long-term folic acid intake with assessment of genetically determined folate metabolism disorders: a randomized controlled trial with an embedded cohort study	Tusupkaliev A. B.	10701220,25
9	The elementary status of the child population of the Western region of the Republic of Kazakhstan	Batyrova G. A.	11844369,60
10	The study of the effectiveness of independent nursing at the primary health care level	Ermukhanova L.S.	8458158,40
11	Correction of toxic effects of reproductive function in rats and their offspring under isolated and combined effects of chromium and gamma radiation	Iztleuov M. K.	14738027,80
12	Comprehensive assessment of caregivers for the elderly at home	Koshmaganbetova G. K.	7651788,95
13	Development of modern scientific strategies for early prediction of disease outcomes in patients with severe traumatic injuries based on the study of endothelial glycocalyx	Sarkulova J.N.	10035224,20
14	Prognostic significance of blood-brain barrier dysfunction in brain damage in patients with cerebral infarction	Hamidulla  A. A.	8531967,20
15	Clinical and functional parameters of the cardiovascular system in children with coronavirus infection and the development of a set of corrective measures	Kim S. V.	8535609,20

 

	Topic	Director	Allocated funds
1	Clinical and immunological aspects of latent autoimmune diabetes in adults in the Kazakh population and the development of recommendations for the management of these patients	H. I. Kudabaeva	11699744,20
2	The importance of interleukin-22, homocysteine, and insulin-like growth factor binding protein-1 (IGFBP-1) levels in the prognosis and diagnosis of premature prenatal rupture of the membranes	S. Y. Shikanova	3485340
3	Early diagnosis of restenosis in patients with acute coronary syndrome after stent implantation	G. L. Kurmanalina	17747232, 55
4	Early diagnosis and treatment of cardiotoxic complications associated with breast cancer chemotherapy	S. K. Balmagambetova	14579526,20
5	Improving the results of treatment of newborns and children of the first year of life using double-barrelled enterostomy with a single-stage intestinal fistula	B.K. Jenalaev	2551023,28
6	Comprehensive assessment of the physiological state of the pubic symphysis in women during pregnancy	G. K. Gubasheva	3264200
7	Prevention of infected pancreatic necrosis in acute destructive pancreatitis	M. K. Dzhakanov	2074028,58
8	The prognostic value of micronutrient metabolism in women of reproductive age in Aktobe region	A. Amanzholovna	2671854
9	The state and improvement of the organization of outpatient care for pregnant women with diabetes in the Western region of the Republic of Kazakhstan	S.T. Tazhbenova	1207421,54

 

	Topic	Director	Allocated funds
1	Assessment of the quality of life of patients with orphan diseases in the Republic of Kazakhstan	Alekenova N. U.	3516742,00
2	Transforming growth factor-β1 and the level of fecal elastase-1 as indicators of pancreatogenic diabetes in the Kazakh population	Bazargaliev E. S.	9485237,54
3	Comprehensive analysis of HPV-positive tumors of the mammary glands, lungs, and intestines: epidemiological, clinical, diagnostic, and genetic aspects	Balmagambetova  S. K.	6793770,18
4	Diagnostic value of S100B whey protein in pregnant women with hypertensive conditions during pregnancy	Gaidai A. N.	4157700,00
5	Biomarkers in assessing the clinical course and effectiveness of treatment of recurrent tuberculosis of the respiratory system	Dilmagambetov D. S.	32093484,00
6	Optimization of ways to prevent gastroesophageal reflux disease after laparoscopic longitudinal gastric resection in patients with morbid obesity	Zhakiev B. S.	1514904,50
7	Capacity building to improve burden of care prevention and assessment of informal caregivers at home	Koshmaganbetova G. K.	1633956,00
8	To study the polymorphism of Toll-like receptor genes in cytomegalovirus infection in children of the Kazakh population	Kurmangazin M. S.	17821591,72
9	Assessment of the intensity of the processes of eryptosis and its role in the development of anemia and hemostasis disorders in patients with cirrhosis of the liver HBV, HCV etiology	Kurmangalieva S. S.	9247498,95

Relevance: In Kazakhstan, the subpopulation of people over 60 years of age is 11.1% of the total population, whereas, for example, in countries like Germany, this figure is 28.0%, in Japan – 33.4% . On the other hand, the birth rate in Kazakhstan reaches 2.6 children per woman, while in Taiwan or Portugal it is only 1.2. Thus, compared to many other countries in the world, Kazakhstanis are still relatively young. However, according to WHO forecasts, the population of Kazakhstan, as well as the population of the whole world, will age, so it is necessary to ask and receive answers to questions about the care of the elderly in advance.

The goal: to study the needs of the elderly in Kazakhstan in order to eventually create an algorithm to meet their needs.

Expected and achieved results:

A meta-analysis of the problem under study has been carried out using the scientific search method for foreign research materials in the Scopus, Google Scholar, and PubMed information databases.
A comparative analysis of the data collected from 4 cities of Kazakhstan was carried out. This work began in May 2021, and according to the results of a survey in Aktobe – 200 people, in Kyzylorda – 200 people, in Shymkent – 400 people, in Uralsk – 200 people were interviewed, according to the EASY Care Standard questionnaire -2010. According to the questionnaire "Care for elderly people in Kazakhstan", Uralsk – 200 people; Kyzylorda – 200 people.
A database has been created. The STATISTICA 13.0 software (TIBCO software, Poland) was used for statistical analysis. Statistical processing of data on the EASY Care Standard -2010 questionnaire was carried out.
In the course of the research, 4 articles were submitted (1 to the Higher Attestation Commission journal, 2 to Scopus, and 1 to Web of Science).
"A non-systematic review of the features of pharmacotherapy in the elderly at the stage of taking medications";
"Medical and social effectiveness of geriatric services in the Republic of Kazakhstan";
"SWOT analysis and expert assessment of the effectiveness of the implementation of medical information systems in polyclinics in Aktobe (Kazakhstan)" for publication in the journals of the scientometric database Scopus with a percentile of at least 50.
1 article has been submitted "The use of the EASY Care Standard-2010 questionnaire in global geriatric practice. Literary Review" is a peer-reviewed scientific publication included in the COXON of the Ministry of Education and Science of the Republic of Kazakhstan and included in the publication plan of the journal "Science and Healthcare" for 2021.

Full name of the research group with their identifiers (Scopus Author ID, Researcher ID, ORCID, if available) and links to relevant profiles:

Head, Leading Researcher (VNS) – Lyudmila Sergeevna Ermukhanova, Associate Professor, Head of the Department of Public Health and Public Health, NAO ZKMU named after Marat Ospanov, ORCID: 0000-0001-7703-9649, Scopus authors ID: 56560101000, Researcher ID: AAP-9928-2020
Senior Researcher (SNA) – Rysty Kaztuganovna Nazarbayeva, Candidate of Medical Sciences, Associate Professor of the Department of Evidence-based Medicine and Scientific Management at the Ospanov Central Medical University, ORCID: 0000-0003-3351-1248
Junior Researcher (MNS) – Indira Temirkhanovna Abdikadirova, PhD in Public Health, Acting Associate Professor of the Department of Public Health and Public Health at the Ospanov Moscow State Medical University, ORCID: 0000-0003-2762-684X, Scopus authors ID: 57191091296, Researcher ID: ABC-9298-2021.

List of publications:

Yermukhanova L., Ismagulova E., Sultanova G., Nazarbayeva R., Sarsenbayeva G. "Medical and social effectiveness of geriatric services in the Republic of Kazakhstan".
Yermukhanova L., Kimatova K., Nazarbayeva R., Dostanova Z., Aimbetova G. "A non-systematic review of the features of pharmacotherapy in the elderly at the stage of taking medications"
Yermukhanova L., Buribayeva Z., Abdikadirova I., Tursynbekova A., Kurganbekova M. "SWOT analysis and expert assessment of the effectiveness of the implementation of medical information systems in polyclinics in Aktobe (Kazakhstan)"
"The use of the EASY Care Standard-2010 questionnaire in global geriatric practice. Literary Review" is a peer-reviewed scientific publication included in the COXON of the Ministry of Education and Science of the Republic of Kazakhstan and included in the publication plan of the journal "Science and Healthcare" for 2021. Authors: Kimatova K.N., Ermukhanova L.S., Sultanova G.D., Ayymbetova G.E., Nazarbayeva R.K., Abdikadirova I.T.

Additional files:
Certificate of entry of information in the State Register of copyrighted objects №30800
А non-systematic review of the quality of life research in patients with glaucoma

Registration number 0121RK00382

RELEVANCE

The development and strengthening of primary health care (PHC) is a priority area of the three WHO Health 2020 strategies. This project is in line with the Development Strategy of the Republic of Kazakhstan for 2019-2025: the development of human resources in the field of healthcare and medical science, the introduction of IT technologies in healthcare.

The current educational program (OP) does not meet the standards of WONCA (WorldOrganizationofFamilyDoctors) for the training of family doctors (CB). She covers clinical issues well, but does not take into account the competence approach and does not develop mentoring.

Clinical mentors are experienced doctors of practical healthcare, but most of them are narrow specialists who completed basic training before the reforms and do not have the skills to transfer knowledge.

According to the recommendations of the European Academy of General Practitioners (EURACT), the following key competencies of GPS are distinguished: management of the care process; patient- and community-oriented care; solving specific patient problems; and a comprehensive and holistic approach.

The achievement of these competencies is well realized with the help of standardized patients (SP). The use of joint ventures ensures the patient's right to receive safe and high-quality care, however, medical universities in the Republic of Kazakhstan do not have trained joint ventures for family doctors, which significantly reduces the quality of education.

The insufficient amount of scientific research in the field of SM also hinders the development of the specialty. The quality of primary health care will increase only through the development of a continuous improvement strategy. Every family doctor should have a "measure-improve-measure" mindset (B.Bagley, 2005).

A big problem is the unavailability of practical healthcare to provide the workplaces of family doctors with appropriate equipment. GP offices do not have ophthalmoscopes, otoscopes, functional couches for examining patients, etc. Therefore, our doctors cannot practice SEE.

Weak IT support for polyclinics does not contribute to improving the service and satisfaction of both doctors and patients. A well-designed, modernized family doctor's office will allow you to manage appointment requests, referrals and prescriptions, introduce electronic communication with patients, and pre-medical online diagnostics.

Given the above, there is an urgent need to develop a modern curriculum for the training of SM residents, train clinical mentors, and create a model of a family doctor's educational and research office, which was the motivation for this project.

 

THE PURPOSE OF THE STUDY

To promote the development of scientific research in the field of family medicine, the development and implementation of new technologies to improve the quality of training of family doctors in accordance with international standards.

 

RESEARCH OBJECTIVES:

1. Conducting a comparative analysis of educational programs in family medicine for compliance with WONCA standards.

A comparative analysis will be conducted in a qualitative study (interviews and focus groups with Kazakhstani and international experts in the field of medical education and primary health care).

The consensus process will be conducted using a nominal group methodology based on web/online communication.

The results of the analysis will be documented in the form of a report, which will become the basis for developing an action plan and a model for training family doctors at the residency level, taking into account international best practices and the specifics of the Kazakh healthcare and education system.

2. Development of an educational residency program in family medicine in accordance with the modern international concept of PHC improvement, piloting and evaluating its effectiveness.

Based on the results of qualitative research, an educational residency program in the specialty "family medicine" will be created. A pilot implementation of the developed program will be conducted and an experimental study of its effectiveness will be conducted based on the following indicators: satisfaction of students, employers, patients, the volume of competencies acquired and used in practical work by a family doctor, hospitalization, referrals to specialized specialists and diagnostic examinations, etc.

Based on the results of the pilot, it is planned to apply for accreditation of the educational residency program in family medicine.

3. To develop mechanisms for continuous training of family doctors to improve the quality of education and improve medical services.

As part of this task, an online course will be developed for clinical mentors (practical healthcare doctors who will master the necessary pedagogical competencies to train residents in medical organizations). It is planned to train teachers in EURACT programs, followed by cascade training. As a result, a regional network of mentors will be created who will participate in the training of residents.

4. Creation and piloting of offices of general practitioners as a new model of educational and research bases that implement the principle of the trinity of science, education and clinic.

As part of the project, offices will be opened, equipped with the necessary equipment for a full-fledged examination of patients and outpatient procedures, in which residents will be able to put into practice all the acquired skills, unlike conditions unsuitable for family reception in existing clinics. In addition, these offices will be equipped with educational equipment, including for simulating situations during training sessions and exams, and for telemedicine, if necessary, counseling. Such office facilities, the availability of computer programs for creating databases and registers, will allow for research work.

5. Creation and implementation of technologies for research and optimization of medical care for the population.

Programs will be created to create patient registers for conducting research in primary care.

Mobile applications for patients with chronic diseases, diagnostic questionnaires, and scales in mobile applications for online consultations will be developed and implemented. patient management and education.

 

EXPECTED RESULTS

The main expected results of the project are:

Accredited educational program for residents in family medicine. Scope of application – medical education, target consumers – residents

The established office of the family doctor. Scope of application – primary health care, practical healthcare, target consumers – population, patients, medical workers

Trained clinical mentors. Scope of application – medical education, practical healthcare, target consumers – general practitioners/family doctors, residents

Scientific research and innovative projects initiated and carried out by residents. Scope of application – primary health care, medical education and science, target consumers – primary health care workers, patients, the population

Reduction of pocket expenses of patients and the population for medicines and medical services by 30%, reduction of hospitalizations, referrals to specialized specialists by 10%.

Based on the results of the implemented tasks and the conducted research, there will be:

1) 3 articles have been published in foreign peer-reviewed scientific journals (European Journal of General Practice, H Index 28, SJR 2019 0.77, https://www.scimagojr.com/journalsearch.php?q=13214&tip=sid ; Journal of Interprofessional Education and Practice, H Index 7, SJR 2019 0.32, https://www.scimagojr.com/journalsearch.php?q=21100403171&tip=sid&clean=O ; Family Medicine, H Index 63, SJR 2019 0.51, https://www.scimagojr.com/journalsearch.php?q=13298&tip=sid ), and 5 articles in KKSON magazines and other publications.

2) a monograph and a textbook have been published in Kazakhstani publishing houses;

3) 3 scientific and practical conferences were held. Scope of application – primary health care, medical education, target consumers – doctors, teachers

4) 2 training courses on the organization of patient-family-society-oriented care have been developed and conducted. Scope of application – primary health care, target consumers – doctors, teachers, the population

5) Mobile applications have been developed for doctors and patients on diagnosis, treatment, prevention, management of chronic patients, training and self-monitoring. Scope of application – primary health care, target consumers – doctors, patients, family members of patients

6) Patient registers have been created for subsequent studies. Field of application – science, primary health care, target consumers – researchers, doctors

7) new local clinical protocols (KP), scientifically and economically sound standards of operational procedures (SOP) have been developed, current protocols, standards, and drug forms in medical organizations have been revised and updated. The field of application is primary health care, consumers are medical professionals

The impact of expected results on the development of the main scientific field and related fields of science and technology.

Applicability and/or possibility of commercialization of the obtained scientific results:

— registration of a franchise for a family doctor's office.

— conducting paid training courses for health workers

— attracting residents who study on a paid basis

— development of scientifically based and economically feasible local protocols, dosage forms, SOPs for primary health care organizations

Social, economic, environmental, scientific, technical, multiplicative and (or) other effects of the project results with justification:

— social impact – we expect a reduction in patients' pocket costs for medicines and medical services. Evidence-based medicine as the basis of medical practice and patient-oriented care make it possible to better and more accurately identify patient problems, reduce the risks of medical errors and overdiagnosis, and reduce unreasonable prescriptions. Our educational program, our patient- and family-oriented business policy, shapes a family doctor who stands up for people's interests. Reducing the cost of maintaining and maintaining health will make it possible to direct people's resources to proper nutrition, improving living and working conditions. In addition to reducing costs, the expansion of rehabilitation and palliative care, which we plan to develop in the family doctor's office, which are now almost not provided at the primary level, will significantly improve the quality of life of patients, increase public satisfaction, which will relieve social tension.

— economic effect – in the short term, in addition to reducing patients' pocket costs, the Ministry of Defense's expenses for day hospital services, purchase of unproven medicines, payment for unnecessary services, reduction of hospitalizations and ambulance calls will decrease.

— scientific and technical – according to the developed mobile applications, the doctor will be able to effectively monitor the condition of patients, this will allow remote online monitoring of patients' health indicators and timely online response in order to correct the condition. Patient data registers will form the basis for statistical analysis of scientific research.

5) other direct and indirect results of the project, indicating their qualitative and quantitative characteristics.

For residents: Development of scenarios for the preparation of standardized patients, preparation of assessment tools, video content for the online platform, a module for the development of research competence of residents. Cycles for residents on PBL, RBL and PBLI technology (practice-based and improvement-based learning) will be developed. Scientific projects will be initiated for residents together with practical healthcare to find effective solutions to urgent problems of primary health care.

Training seminars have been held for chronic patients and PHC volunteers.

For mentors: assessment tools for integrated OCE stations, educational video content has been created on an online platform.

 

ACHIEVED RESULTS

1. A pilot 2-year educational program (OP) of the residency in the specialty "Family Medicine (CM)" has been developed, taking into account the needs of practical healthcare, the real conditions of the clinical bases of the residency (urban polyclinics and outpatient clinics), the requirements of current regulatory legal acts on the organization of the educational process (for example, the duration of training, the ratio of credits, etc.), the incoming level of knowledge, skills and attitudes of internship graduates, but at the same time, focused on international standards of family doctor training. In particular, the competencies of WONCA family doctors, the international Association of Family Physicians, were used to compile a list of the final learning outcomes. The list of practical skills in the current SES 2019 and TUE has been almost completely (by 70%) changed (order of the Ministry of Health of the Republic of Kazakhstan dated July 31, 2015 No. 647 as amended by the Order of the Ministry of Health of the Republic of Kazakhstan dated 02/21/2020), the list of the most common diseases and conditions to be diagnosed and treated, new disciplines have been introduced, for example, on scientific research in SEE Leadership in Primary Health Care (PHC), and others. OP policies are provided, and the list of assessment tools for residents has been expanded.
2. 1 teacher, a member of the temporary scientific staff of the NTP, was trained at the EUROACT training "Leadership in family medicine" for teachers of family medicine in Bled (September 9-11, 2021). The certificate has been submitted. Leadership as a competence is included in the tasks of the new OP, in the PHC Management module. The developer and responsible teacher of this module is L.M. Zhamalieva, who completed this Euroact training. In January 2022, L.M. Zhamalieva will conduct a master class for teachers on leadership in family medicine based on the training materials.
3. An online course has been developed for clinical mentors of family medicine residents. The Moodle platform is used. The objectives of the course are to develop the pedagogical competencies of clinical mentors, to improve the understanding of the principles of family medicine among clinical mentors, especially among narrow specialists, under whose guidance residents develop their practical skills in neurology, ophthalmology, etc. The main end results of mentors' training are the formation of their clinical training skills for residents, educational feedback, and commitment to the practice of evidence-based medicine. Taking into account the employment of mentors-practitioners, the developed online course is designed for 6 months: 1 module (2 credits) for 2 months. The online course platform will feature self-study materials, video lectures, self-monitoring questions, a forum for discussion and feedback from course teachers, and other learning resources.
4. Two articles have been published: one in the journal from the list of COXON, the second in the journal of the Ministry of National Security of the Russian Academy of Sciences.
   — N.A. Abenova, G.S. Dilmagambetova, L.M.Zhamalieva, A.R. Kashkinbayeva, Yu.A.Zame, G.K. Koshmagambetova. Comparative review of educational programs in family medicine in Kazakhstan and in the world. Science and Healthcare, 2021, No. 4 (vol.23), pp. 153-161.
   — Z.Zh. Tanbetova, G.S. Dilmagambetova, M.B. Akhmetzhanova, L.M. Zhamalieva. The attitude of family medicine residents towards their profession: the results of a qualitative study. West Kazakhstan Medical Journal, No. 63 (3), 2021, pp. 138-144
5. The international scientific conference "Residency in Family Medicine: achievements, problems and prospects" on the problems of residency in the specialty "Family Medicine" was held on May 19-20, 2021, in Aktobe (Kazakhstan).
   Reports:
   - Abenova N.A. at 12:10 "Comparative review of educational programs on family medicine residency in Kazakhstan and in the world"; PDF
   - Kashkinbayeva A.R. at 12:45 p.m. "A new experience in organizing a training module on pediatric neurology for resident family doctors"; PDF
   - Tanbetova Z.J. at 13:15 "The attitude of family medicine residents to their profession: the results of a qualitative study"; PDF
   - Zame Yu.A. "Communication with elderly patients in the practice of a family doctor" (poster presentation); PDF
   - Resident Tattibaeva A. "The perception of professionalism among students and residents of medical universities (qualitative research)" (II prize). PDF

 

Research Group and project management

1. Zhamalieva lazzat Manbetzhanovna candidate of Medical Sciences, Associate Professor-Scientific Head of the project, Hirsha index-1

Scopus Author ID 57204944725

https://www.scopus.com/authid/detail.uri?authorId=57204944725

ORCID ID 0000-0003-3625-3651

2. Abenova Nurgul Abdullaevna - candidate of Medical Sciences.

Scopus Author ID 57191709378

https://www.scopus.com/authid/detail.uri?authorId=57191709378

3. Dilmagambetova Gaukhar Saruarovna - candidate of Medical Sciences, Hirsha index-1

Scopus Author ID 8634838700

https://www.scopus.com/authid/detail.uri?authorId=8634838700

4. Koshmaganbetova Gulbakyt Kuanyshkalievna - PhD, Index Hirsha-3

Scopus Author ID 56560058000

https://www.scopus.com/authid/detail.uri?authorId=56560058000

ORCID ID 0000-0001-5895-346X

5. Ostretsova Tatyana Petrovna - candidate of Medical Sciences.
6. Tanbetova Ziyash Zhakanovna - master of medical science.

Scopus Author ID 57283771200

https://www.scopus.com/authid/detail.uri?authorId=57283771200

7. Akhmetzhanova Moldir Bekmaganbetovna - master of medical science.
8. Tautanova Aidana Kurmanbaikyzy - master of musical science.

Scopus Author ID 57220175835

https://www.scopus.com/authid/detail.uri?authorId=57220175835

ORCID ID 0000-0001-8971-1455

 

List of publications within the framework of a scientific and technical project with grant funding for scientific and (or) scientific and technical projects for 2021-2023 on the topic:

• IRN AP09260428 "Capacity building of medical education technologies and scientific research in family medicine in Kazakhstan" PDF
• N.A. Abenova, G.S. Dilmagambetova, L.M.Zhamalieva, A.R. Kashkinbayeva, Yu.A.Zam, G.K. Koshmagambetova. Comparative review of educational programs in family medicine in Kazakhstan and in the world. Science and Healthcare, 2021, No. 4 (vol.23), pp. 153-161. PDF

https://newjournal.ssmu.kz/publication/448/2021-4-23-190-198/?sphrase_id=8312180

 

Articles in scientific and practical journals:

• Z.Zh. Tanbetova, G.S. Dilmagambetova, M.B. Akhmetzhanova, L.M. Zhamalieva. The attitude of family medicine residents towards their profession: the results of a qualitative study. West Kazakhstan Medical Journal, No. 63 (3), 2021, pp. 138-144 PDF

 

Copyright certificate:

1. Certificate of entry of information in the State Register of copyrighted objects №30147:
   Professionalism in medicine: methods of teaching and evaluation (educational and methodical manual)
2. Certificate of entry of information in the State Register of copyrighted objects № 32417:
   Using Google Forms to evaluate the quality of test assignments and the effectiveness of training for medical professionals
3. Certificate of entry of information in the State Register of copyrighted objects № 30140:
   Core competencies for medical professionals in the field of evidence-based practice: methods of teaching and assessment (educational and methodical manual)

Acts of implementation:

1. Act of Research Work Implementation:
   Analysis of the actual nutrition of patients with type 2 diabetes by conducting a questionnaire (questionnaire on the study of actual nutrition)
2. Act of implementation on educational and methodical work №182511:
   Implementation of the validated P-mex tool for assessing the skills of 7th year interns
3. ACT №267 of Research Work Implementation:
   Women's reproductive health in the oil and gas region of Western Kazakhstan
4. ACT of Research Work Implementation:
   Teaching patients with type 2 diabetes at the School of Health on diabetes mellitus how to use the capabilities of the NUTRILOGIC program in their daily diet.

Contract with the Ministry of Education and Science of the Republic of Kazakhstan / No. 178/30-22-24 from 18.10.2022

Name of the priority direction of science development

5 – Life Science and Health

Key words , characterizing the industry and direction of the research

SARS-CoV-2, QazVac, SputnikV, humoral immune response ,cellular immunity , post COVID 19 condition

Years of implementation

01.07.2022-31.12.2024, 30 months

Research goal

To research the effect of vaccination with the domestic vaccine QazVac on the indicators of cellular and humoral immunity in patients with a post COVID 19 condition among the population of Western Kazakhstan in order to identify risk factors for its occurrence.

Project objectives

1.To study the prevalence and epidemiological features of the development of the post COVID condition, depending on the status of vaccination, the level of awareness and adherence to vaccination.

2.To study the features of humoral and cellular immunity in patients with post-COVID syndrome, depending on the status of vaccination and in the control group, vaccinated with the domestic vaccine QazVac.

3.To study the clinical and laboratory indicators of the manifestations of the post COVID 19 condition in patients after vaccination with the domestic QazVac vaccine, Sputnik V vaccine and unvaccinated.

4.Identify risk factors for post-COVID 19 conditions depending on vaccine status and develop a risk map.

Relevance

After an acute infection with COVID 19, some patients still have health problems. To date, little is known about specific T-cell responses and antibodies in patients with a post-COVID 19 condition, and risk factors contributing to the onset of a post-COVID 19 condition have not been identified.

In this regard, within the framework of a scientific project, the prevalence of conditions after COVID 19 will be studied, the level of commitment of the population of Aktobe to vaccination against COVID 19 and confidence in the domestic vaccine QazVac will be determined. The research will study the humoral and cellular components of natural and post-vaccination immunity in 3 categories of patients: patients with post-COVID syndrome, vaccinated with the domestic QazVac vaccine, SputnikV vaccine and those who have not been vaccinated. A control study of immunoglobulins and lymphocyte populations will be carried out in individuals after vaccination with the domestic QazVac vaccine.

A comparative analysis of clinical, laboratory and immunological parameters (immunoglobulins and lymphocyte populations), as well as in healthy individuals who received the QazVac vaccine, will be carried out.

Expected results

The results of epidemiological studies will be the identification of the level of public commitment to vaccination against COVID 19, as well as confidence in the domestic vaccine. The main sources of information that inspire confidence among the population to understand the need for vaccination will be identified. A web questionnaire will be developed, an author’s certificate will be obtained. The obtained results of epidemiological studies will make it possible to substantiate recommendations to general practitioners to work with the population on vaccination. The online questionnaire will be in demand by public health specialists to identify awareness and commitment of various strata to vaccination.
The result of the study of clinical and immunological changes (conditions, deviations) that occurred in patients with a post-covid condition: without vaccination, vaccinated with QazVac vaccine and SputnikV vaccine. A risk map will be developed depending on the vaccination status and an author’s certificate will be obtained.

3 undergraduates will be trained.

 It is planned to publish articles in foreign peer-reviewed scientific journals, presumably:

– 2 articles will be published in scientific publications in the scientific direction of the project, indexed in the Web of Science and Scopus databases, with a CiteScore percentile in the Scopus database of at least 35 (thirty-five);

– 3 articles or reviews will be published in a peer-reviewed foreign or domestic publication recommended by the CQAFSHE; (Committee for Quality Assurance in the Field of Science and Higher Education)

 It is planned to participate in international conferences / congresses with the publication of abstracts – 3. Acts of implementation in practical healthcare 2 will be issued

The final product of the study is to write a monograph, which will present the results on the topic under study, namely the epidemiological, clinical and immunological features of post-covid conditions in the population of Aktobe.

Results achieved in 2022

A web-questionnaire was developed in 2 languages and a copyright certificate was received. The participant’s IRC and informed consent forms were developed and replicated, the researcher’s magazines and brochures (instructions) were developed. Members of the research group were trained to conduct the study, fill out documentation and work with the database. Questionnaires are being sent out among the population of Aktobe, 817 questionnaires have been collected. A database of patients with post-covid syndrome is being studied in 3 polyclinics in Aktobe for the selection of patients and people in the control group for the study.

Supervisor

Urazaeva T.Saltanat – Candidate of Medical Sciences, Associate Professor, Head of the Department of Epidemiology.

She has about 100 scientific publications, of which 4 are published in scientific journals indexed in the Web of Science and Scopus databases; author of 8 textbooks.

Research interests: epidemiology of infectious and non-infectious diseases, vaccinology. She was the head of the scientific and technical program funded by the university – “Studying the epidemiological patterns of the course of anthroponotic infectious diseases among adolescents and adults in the Aktobe region” (2016-2017) and a participant in the scientific and technical program funded by the Ministry of Health of the Republic of Kazakhstan “National program for the introduction of personalized and preventive medicine in Republic of Kazakhstan” 2021-2023 (IRN OR12165486)

 Urazaeva S.T. – Scopus Researcher ID-57208062042

Urazaeva S.T. – Web of Science Researcher ID – ABF-6482-2021

TRT

Saltanat T.Urazayeva, Candidate of Medical Sciences, Associate Professor, Head of the Department of Epidemiology of NJSC “WKMU named after Marat Ospanov” – Leading Researcher, Project Manager; https://orcid.org/0000-0002-4773-0807;
Kurmangalieva S.Saule , Candidate of Medical Sciences Head of the Department of Microbiology, Virology, Immunology of the NJSC “WKMU named after Marat Ospanov”– senior researcher of the project;  https://orcid.org/0000-0002-9502-1490;
Tusupkalieva Sh.Kymbat, Candidate of Medical Sciences, docent of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – senior researcher of the project; https://orcid.org/0000-0002-6980-378X;
Seitmaganbetova A.Nazgul, Candidate of Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases of the NJSC “WKMU named after Marat Ospanov” – senior researcher of the project.  https://orcid.org//0000-0002-7718-4464
Begalin Toleukhan, Candidate of Medical Sciences, Senior teacher of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – researcher of the project;  https://orcid.org//0000-0003-2338-6236;
Urazaeva B.Aisha, PhD, Acting Associate Professor of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – senior researcher of the project; https://orcid.org/0000-0001-5978-2957;
Tashimova K.Zhuldyz, Master МВА, Senior lecturer of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – researcher of the project; https://orcid.org//0000-0001-7708-2049;
Baktikulova V.Kristina, laboratory doctor at the Medical Center of the NJSC “WKMU named after Marat Ospanov” – junior researcher of the project; https://orcid.org//0000-0003-1806-1058;
Begalina T.Dana, Assistant of the Department of General Medical Practice №2 of the NJSC “WKMU named after Marat Ospanov” – junior researcher of the project; https://orcid.org//0000-0003-0162-5005;
Zhumagalieva K.Saltanat , Master of Technical Sciences, Junior Researcher of the Department of Management of Research Activities of the NJSC”WKMU named after Marat Ospanov” – junior researcher of the project;

 

2023 articles:

• Kazakhstan Journal of Medicine and Pharmacy, 2023 X International Scientific Conference of Young Scientists and Students "Prospects for the development of biology, Medicine and Pharmacy"
• Microbiology and Virology
• Collection of materials of the scientific and practical conference with international participation "Modern trends in laboratory medicine for clinical practice", 1st part
• Collection of materials of the scientific and practical conference with international participation "Modern trends in laboratory medicine for clinical practice", Part 2
• Pharmacy of Kazakhstan

 

2024 articles:

• Features of the immune response in patients with the neurological variant of post-COVID-19
• Features of humoral and cellular immune response in patients with respiratory variant of bridge syndrome
• COVID-19 vaccination: Acceptance and indecision
• Post-covid syndrome and its relation to vaccination against COVID - 19 (based on the results of a literature review)
• Attitudes towards vaccination against COVID-19 and the adoption of the national vaccine “KazWak” among the population of Aktobe, Western Kazakhstan: Cross-examination
• Risk factors associated with the long-term spread of covid-19: A descriptive review

 

Additional files:

• Patents and certificates
• Acts of implementation
• Methodical recommendation
• The monograph

Registration number: 0123РК00860, № 13/8-21-2637, 12.09.2023.

Scientific supervisor: Батырова Гульнара Арыстангалиевна, PhD, Head of the Department of Clinical Laboratory Diagnostics

Hirsch index 4

Scopus Author ID 57195269858

ORCID iD 0000-0001-7970-4059

Web of Science Researcher ID AAP-5352-2020

Place of implementation: West Kazakhstan Marat Ospanov Medical University

Relevance: Within the framework of the national project “Quality and affordable healthcare for every citizen” Healthy Nation “, which is being implemented in the country, special attention is paid to preserving and strengthening the health of children. At the same time, great importance is given to the task of ensuring wide coverage of the population with healthcare services, especially in rural areas.

The aim of the project is to study the state of the elemental status of the child population as an indicator of the availability of micronutrients for children and the impact of environmental pollutants, especially in rural areas.

Purpose of the study: To study the elemental status of the child population of the Western region of the Republic of Kazakhstan.

Practical significance and novelty: For the first time in Kazakhstan, the influence of elemental status on physical development will be assessed using WHO standards. For the first time, the features of the elemental status of children in rural areas will be revealed. The data obtained during the study will be demonstrated in an online atlas with the visualization of regional differences in the content of elements in children in Western Kazakhstan. The functionality laid down in the development of the online atlas, the flexibility of the technologies with which it will be implemented, make it simple and accessible to the general public.The online atlas will offer children’s elemental status data as interactive, geo-referenced maps, in a simple and understandable way, and will be publicly available. The information obtained will allow substantiating further corrective measures to compensate for the deficiency of micro- and macroelements by the food method.

Results obtained for 2023:

According to the calendar plan, during scientific trips, hair was collected from children and adolescents permanently residing in Martuk, Baiganinsky, Temir, Kargalinsky, Uilsky, Khobdinsky, Mugodzharsky, Irgizsky, Aitekebiysky, Khromtausky, Shalkarsky, Alginsky oblasts of the Aktobe region and in the city of Aktobe. An assessment of the elemental status of children was carried out.

An assessment of the physical development of the child population of the Aktobe region was carried out. Work was carried out to develop maps of the elemental status of the child population of the Aktobe region. The interactive cartogram of the online atlas displays the elemental status of the child population of the Western region of the Republic of Kazakhstan (currently in the Aktobe region). Maps of the elemental status of the child population of the Aktobe region of the Western region of the Republic of Kazakhstan were compiled.

Abstracts published in collections of materials of international conferences:

1. Batyrova G.A., Taskozhina G.E., Umarova G.A. Assessment of the content of conditionally essential microelements by mass spectrometry in the child population of the Western region of the Republic of Kazakhstan // Collection of materials of the scientific and practical conference with international participation “Modern trends in laboratory medicine for clinical practice”. – Astana: NJSC “Astana Medical University”, 2023. – P.23-24

2.Taskozhina G.E., Serikbaeva N.R. Analysis of calcium and phosphorus content in biosubstrates of children and adolescents using the mass spectrometry method // Collection of materials of the scientific and practical conference with international participation “Modern trends in laboratory medicine for clinical practice”. – Astana: NJSC “Astana Medical University”, 2023. – P.70

Registration number: 0123РК00899, 13/8-21-2715, 18.09.2023.

Scientific supervisor: Knissarina Malika Maksatovna, Doctor of Philosophy (PhD), Associate Professor of the Department of Psychology, ORCID: 0000-0002-7350-1768 (https://orcid.org/0000-0002-7350-1768), Scopus authors ID: 57192387506 (https://www.scopus.com/authid/detail.uri?authorId=57192387506), Researcher ID: Q-6386-2018 (https://publons.com/researcher/1867176/malika-m-knissarina/).

Place of implementation: this scientific project has been implemented at the Department of Psychology of West Kazakhstan Marat Ospanov Medical University since 2023

Relevance: According to UNICEF Kazakhstan (https://www.unicef.org/kazakhstan/media), the development of an independent, civic personality of youth, the formation of their positive worldview while preserving the national-state identity and cultural originality is recognized as the weakest domain in the Kazakhstan Index Assessment well-being of youth.

In this regard, at the beginning of 2021, the President of the Republic of Kazakhstan, Kassym-Jomart Tokaiyev, instructed to develop a Youth Development Index for the country: “According to world practice, it is necessary to introduce a youth development index in Kazakhstan. The work of 36 local authorities to implement youth policy will be assessed on the basis of this criterion,” since the well-being of youth is included in the system of state priorities aimed at expanding the opportunities of the younger generation for effective self-realization, successful socialization, as well as the growth of human capital, contributing to the achievement of sustainable social economic development, competitiveness and national security of the country.

The study will expand knowledge in the field of the Youth Well-Being Index, factors contributing to the creation of an attractive environment for active youth with a strong civic position (volunteering, participation in social and professional projects, summer work teams, internships, improvement work, etc.). At the same time, an analysis of the main indicators of the well-being of studying youth using the example of Western Kazakhstan will contribute to the creation of a holistic understanding of the socio-psychological levers that influence the intensive growth of the well-being of studying youth, and, as a result, the identification of an appropriate forecast for the effective course of this process.

Purpose of the study: theoretical justification and identification of socio-psychological opportunities for intensive growth of well-being for effective self-realization and further professional development of students using the example of West Kazakhstan.

Practical significance and novelty: The expected social and economic effect from the results of the implementation of this project is seen in increasing the intensive growth of well-being of the studying youth of Western Kazakhstan, in identifying the conditions necessary for their effective development in the field of youth policy. This study expands knowledge in the field of well-being and development of students, in particular in clarifying the basic concepts of “personal well-being”, “social and psychological well-being of the individual”, “youth well-being index”, “assessment of the well-being of students”, in determining the criteria for the Well-Being Index youth (civic participation, economic opportunity, education, health, information and communications technology, safety and security).

Results obtained for 2023:

1) The essential characteristics and conceptual foundations of the concepts of “personal well-being”, “socio-psychological well-being of the individual”, “youth well-being index”, “assessment of the well-being of studying youth” are analyzed based on the theories of: R. Ryan and E. Deci, self-determination theory, the theory of psychosocial development of D. Havighers, the theory of N. Hartmann, F. Vernon, the sociocultural theory of development of J. Bruner and others. The analysis demonstrates that the Youth Well-Being Index is an important tool for measuring and analyzing the quality of life of young people. Its role is to measure the quality of life of young people, compare between regions and countries, monitor changes in well-being over time and set priorities for the development of policies and programs to support young people. The Index plays an important role in assessing and improving the lives of young people and in shaping effective public policies and programs to support them. The component criteria of the Youth Well-Being Index have been identified: civic participation, economic opportunity, education, health, ICT, safety and security.

2) From 09/26/2023 to 09/30/2023. researchers (Knissarina M.M., Miraleyeva A.I., Syzdykbayeva A.D.) completed an internship and received consultations from foreign scientists at the St. Petersburg State University of Telecommunications. prof. M.A. Bonch-Bruevich (St. Petersburg, Russia). The purpose of the internship was to discuss the socio-psychological conditions for the intensive growth of well-being of students in the conditions of professional training at the university.

Internship program (download file)

Internship certificates (download file)

Aim - Development of an innovative domestic kit (exosomes) for the treatment of degenerative diseases (regenerative medicine) of connective tissue, as well as oncopathology of various localization (lung cancer, breast cancer, colorectal cancer).

 

Tasks:

1. Creation of an original technology for obtaining a culture of mesenchymal stromal/stem cells (MSCs) from the umbilical cord;
2. Development of a technique for isolating exosomes from MSCs for the treatment of degenerative diseases;
3. Evaluation of the qualitative characteristics obtained by exosomes;
4. Conducting a comparative analysis of the effectiveness of the developed innovative set of exosomes and existing expensive commercial sets;
5. Organization and conduct of preclinical trials of the developed innovative set of exosomes: safety testing, determination of the method of administration, the optimal dose for patients with degenerative diseases and oncopathology;
6. Organization and conduct of clinical trials of the developed innovative set of exosomes (phase I) for patients with degenerative diseases and oncopathology.

 

Expected Results:

Direct results:

Obtaining new scientific knowledge on the development of regenerative medicine using nanotechnology aimed at the treatment of degenerative diseases of connective tissues and oncopathology of various localizations (lung cancer, breast cancer, colorectal cancer) of the population of the Republic of Kazakhstan.

Target performance indicators:

1. Development of a more accessible domestic innovative method for isolating exosomes from MSCs culture for the treatment of patients with connective tissue diseases and oncopathology (lung cancer, breast cancer, colorectal cancer).
2. Scientific substantiation of the effectiveness of the developed domestic kit, which is not inferior to commercial kits of foreign production both in terms of the number of intact isolated exosomes, and in size and degree of purification.
3. To study the ability of the developed kit to eliminate protein contamination for the production of a "clean product".
4. Scientific justification of the possibility of reducing healthcare costs through the introduction of cost-effective and effective treatment methods in rheumatology and oncology, which corresponds to the country's goals of providing affordable and affordable medical care to the population.

 

Strategically Important National Tasks Addressed by the Program:

1. The concept of healthcare development of the Republic of Kazakhstan until 2026, approved by the Decree of the Government of the Republic of Kazakhstan dated November 24, 2022 No. 945. Section 5. The main principles of the industry development 2.2. Ensuring the availability of specialized, including high-tech, medical care.
2. The concept of development of higher education and science in the Republic of Kazakhstan for 2023-2029, approved by Resolution of the Government of the Republic of Kazakhstan dated March 28, 2023 No. 248. Section 5. Basic principles and approaches. Chapter 3. The development of science. Paragraph 2. Strengthening intellectual potential. Paragraph 5. The development of applied science and the ecosystem of commercialization of the results of scientific and scientific-technical activities.

 

Program Location: Republic of Kazakhstan

Non-commercial Joint-Stock Company “West Kazakhstan Marat Ospanov Medical University”

Limited Liability Partnership “National Center of Biotechnology” 

Non-commercial Joint-Stock Company “Astana Medical University”

Kazakh Scientific Center of Dermatology and Infectious Diseases of the Ministry of Health of the Republic of Kazakhstan

 

Planned Program Start and End Dates and Duration in Months: 01.09.2024 – 31.12.2026 (28 months)

Aim – Develop a comprehensive monitoring methodology designed for: a) analyzing the dynamics of pre-suicidal conditions among adolescents and young adults (aged 16 to 40); b) identifying intrapersonal and social-environmental factors that determine susceptibility to suicidal behavior in individuals or social groups; c) providing scientific and informational support for measures to prevent suicidal behavior and optimize healthcare, education, social, and youth policies in Kazakhstan.

Tasks:

1. Identify the bio-psycho-social determinants of suicidal behavior
2. Determine the underlying mechanisms of suicidal behavior
3. Develop suicide prevention measures
4. Implement suicide prevention measures into clinical practice among the population of Kazakhstan
5. Identify root causes and risk and protective factors in suicidal behavior, considering their short- and long-term impacts in the context of social and cultural characteristics of the country and regions
6. Conduct a meta-analysis and international review of key factors affecting suicidality and develop effective suicide prevention strategies, including risk and protective factors and intervention effectiveness
7. Evaluate leading international practices and assess the feasibility of using various questionnaires for evaluating the invariance of suicidality measurement constructs
8. Conduct a national sociological multilevel study across Kazakhstan to assess public perception and key trends associated with suicidality and identify relationships between variables at the individual (e.g., level of condemnation/taboo, understanding/empathy, influence of social networks, and cultural norms, accessibility and assistance, education, and prevention) and regional levels
9. Interpret collected data and determine a sociological measurement matrix for suicidality, applying deprivation and social fragmentation indexes to assess the prevalence of suicidal thoughts, attempts, and completed suicides, and conduct statistical monitoring of suicidal behavior across regions
10. Identify the social aspects of suicidality based on the obtained data, including
11. a) levels of social support, increased/reduced sense of isolation and support during crisis situations,
12. b) family relationships,
13. c) education level and access to education,
14. d) economic factors (poverty, unemployment, and economic instability),
15. e) social isolation and stigma associated with mental health
16. Prepare recommendations for the development of feasible short-, medium-, and long-term measures and policies to reduce cases of suicidal behavior, including programs and communication strategies that can be implemented with the support of all relevant government bodies and decision-makers in Kazakhstan
17. Disseminate results and findings of this research in the social, educational, and managerial fields.

Expected Results:

– New data on common and Kazakhstan-specific mechanisms and factors that increase and decrease suicide risk among adolescents and young adults in Kazakhstan

– Reliable bio-psycho-social indicators of suicide risk and their interrelationships in the studied population will be identified

– Global experience and best practices will be examined for potential transfer or adaptation to the Kazakhstani context

– The effectiveness of preventive and rehabilitative interventions will be assessed, followed by the development of recommendations for the medical, social, educational, and managerial fields

– Information resources will be prepared for end-users of the project.

Strategically Important National Tasks Addressed by the Program:

1. Law of the Republic of Kazakhstan dated February 18, 2011 No. 407-IV “On Science”
2. Kazakhstan’s Development Strategy until 2050
3. The Concept of Development of Higher Education and Science in the Republic of Kazakhstan for 2023-2029, approved by the Government of the Republic of Kazakhstan on March 28, 2023, No. 248, Action Plan point 28
4. Protocol of the meeting of the National Council on Science and Technology dated April 12, 2023, point 2.2
5. Address of the Head of State K-J. Tokayev to the people of Kazakhstan “Economic Course of a Fair Kazakhstan” dated September 1, 2023, point 52 of the National Action Plan
6. Environmental Code of the Republic of Kazakhstan dated January 2, 2021 No. 400-VI.

Program Location: Republic of Kazakhstan

– Non-commercial Joint-Stock Company “West Kazakhstan Marat Ospanov Medical University”

– Non-commercial Joint-Stock Company “Semey Medical University”

– Republican Scientific and Practical Center of Mental Health, Ministry of Health of the Republic of Kazakhstan.

Planned Program Start and End Dates and Duration in Months: 01.07.2024 – 31.12.2026 (30 months)